The effect of serum insulin like factor Ⅰ on mouse cancer
- VernacularTitle:血清胰岛素样生长因子-1影响小鼠肿瘤模型的实验研究
- Author:
Shan ZHANG
;
Guoqing CHEN
;
Shihui MA
;
Feng GAO
;
Hongbo TANG
;
Yiping WU
- Publication Type:Journal Article
- Keywords:
Insulin-like growth factor Ⅰ;
Models,animal;
Neoplasms
- From:
Journal of Chinese Physician
2008;10(3):324-327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effect of different serum insulin-like growth factor-Ⅰ(IGF-1)levels on mouse cancer.Methods A total of 120 male mice at 6 weeks of age(60 control mice and 60 LID mice)were subcutaneously injected colon tumor CT26 cell line.Each group was random divided into two subgroups respectively,every 10 mice of one subgroup were injected subcutaneously with growth hormone(GH)(1ms/kg)daily from the 10th,14th and18th days respectively until the 22nd days,and the other subgroup received saline injection.Results All mice treated with GH have higher level of IGF-1,compared with those treated with saline.High level of IGF-1 promoted the development of cachexia in these mice treated with GH from the 10th days.However,the level of IGF-1 has negative correlation with the cancer cachexia state for mice treated with GH from the 14th days.Conclusion Circulating IGF-1 and GH play an important role in tumor growth 4nd cachexia development in the early stage of cancer and can ameliorate the state of cachexia in the advanced stage.
