The characteristics of arrhythmias and efficacy of amiodarone in uremic cardiomyopathy
- VernacularTitle:尿毒症心肌病心律失常的特点及口服胺碘酮治疗的疗效分析
- Author:
Haibo CHEN
- Publication Type:Journal Article
- Keywords:
Uremia;
Cardiomyopaties;
Arrhythmia;
Anaiodarone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(3):373-374
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of arrhythmias and the efficacy and safety of oral amiodarone in uremic cardiomyopathy complicated with severe ventrieular arrhythmias.Methods 86 patients with uremic cardiomyopathy underwent ECG,ambulatory ECG and and echocardiograplly.45 of 86 palients with severe ventricular arrhythmias were orally given amiodarone(0.2g,tid×5d,0.2g,bid×5d,maintenance dose 0.2g,qd),ambulatory,ECG was followed up 10 days after amiodarone loading.Results Arrhythmias was detected in 62 of 86 patients with uremic cardiomyopathy,56 of 62 had ventricular arrhythmias,45 of 56 patients with vemricular arrhythmias was defined as severe because of frequent(＞30/h)or repetitive(＞5 couplets/24h or＞1 salvos of or＞3).48 of 62 patients were supraventrieular arrhythmias.Ventricular arrhythmias were sigrtificantly reduced in 45 partients on amiodarone treatment,28 of 45 patients were significant effective and 13 of 45 cases were effective,the efficacy is 91.1%.Systolic blood pressure and heart rate were not changed significantly after 10-day amiodarone reatment compared with that of untreatment.Only one patients experienced sinus bradycardia(45～55 beats per minute)and swspended after discontinuation of oral amiodarone.Conclusion In patients with uremic cardiomyopathy,arrhythmias were common on ambulatory recording,oral amiodarone was effective and safe for patients with severe ventricular arrhythmias.
