A study on the mechanism of iodine-induced thyroid epithelial cell injury in the induction of autoimmune thyroiditis
- VernacularTitle:碘致甲状腺滤泡上皮细胞损伤在甲状腺炎发生机制中的探讨
- Author:
Xiaochun TENG
;
Na MAN
;
Zhongyan SHAN
;
Chenling FAN
;
Hong WANG
;
Rui GUO
;
Weiping TENG
- Publication Type:Journal Article
- Keywords:
Iodine;
Thyroiditis,autoimmune;
NOD.H-2h4 mice
- From:
Chinese Journal of Internal Medicine
2008;47(3):193-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of iodine excess on thyroid follicle epithelial ultrstructure and the relationship between thyroid iniury and autoimmune thyroiditis. Methods NOD.H-2h4 mice and Kunming mice were randomly divided into four groups receiving plain water,5 fold,10 fold,and 100 fold excessive iodine water.4,8 and 24 weeks after receiving iodine water,the mice were killed.After fixation with osmic acid and dual staining with uranyl chloride and citrate lead,thyroid gland ultrstructure was examined with electron microscopy.Resuits Iodine treated NOD.H-2h4 mice exhibited marked accumulation of peroxisome and secondary lysosomes,apoptosis and necrosis of thyroid epithelial cell.damage of thyroid follicles and lymphocvtic infiltration.The observed changes induced by iodine were in a dose dependent way.Conclusion The oxidative iniury on the thyroid epithelial cells induced by iodine excess might be the prerequisite for the creation of autoimmune thyroiditis.
