Primary biliary cirrhosis complicated with interstitial lung disease
- VernacularTitle:原发性胆汁性肝硬化患者肺间质病变的临床分析
- Author:
Min SHEN
;
Xuan ZHANG
;
Fengchun ZHANG
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis,biliary;
Lung diseases,interstitial;
Prognosis
- From:
Chinese Journal of General Practitioners
2008;7(3):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze clinical features and prognosis for the patients of primary biliary cirrhosis (PBC)complicated with interstitial lung disease(ILD).Methods Medical records of 139inpatients of PBC were retrospectively analyzed and their clinical features,biochemical parameters,spectrum of autoantibodies and Maye risk score were compared between subgroups with and without ILD.Resuits Among twenty two(16%)patients of PBC complicated with ILD,50 percent had respiratory symptoms such as chest distress,short breath,cough,and so on,and 50 percent had diffusing and obstructive ventilation impairment by pulmonmary function test.Patients of PBC complicated with ILD had a faster erythrocyte sedimentation rate(ESR)than that in those without ILD(P＜0.05).There was no significant difference in other biochemical parameters,positive rates of autoantibodies and Mayo risk score between the two subgroups (P＞0.05).Logistic regression analysis showed that odd ratios(ORs)of Raynoud's phenomenon and other connective tissue diseases(CTD)complication in patients of PBC to develop ILD were 3.54 and 2.56(P=0.03 and P=0.05),respectively,though 46 percent of PBC patients with ILD did not have other CTD complications.Conclusions Half of the patients of PBC complicated with ILD have respiratory symptoms.PBC patients with Raynoud's phenomenon and other CTD complications are more likely to develop ILD,but those without complications can also do.
