Toxicity and efficacy of post-operative chemoradiotherapy for gastric cancer
- VernacularTitle:胃癌术后三维适形或调强放疗加化疗的毒性及初步疗效分析
- Author:
Guichao LI
;
Zhen ZHANG
;
Weilie GU
;
Weigang HU
;
Yingqiang SHI
;
Jin LI
- Publication Type:Journal Article
- Keywords:
Gastric neoplasm/radiotherapy;
Gastric neoplasm/chemotherapy;
Toxicity;
Outcome
- From:
Chinese Journal of Radiation Oncology
2008;17(3):203-205
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the toxicity and efficacy of post-operative chemoradiotherapy for gastric cancer. Methods Forty-five gastric cancer patients treated with post-operative radiation ± concurrent chemotherapy were retrospectively analyzed. Among them, 14 were female and 31 were male. The median age was 54 (30-72) years. Pathology stages were IB-IV. Radiotherapy of doses from 45 Gy/25fx to 55 Gy/30fx was delivered to the tumor bed and regional lymph nodes with 3D conformal or IMRT technology.Concurrent chemotherapy agent was fluorouracil or capacitabine. Results All patients except 2 (4%)completed radiotherapy as planned. The most common acute toxicities were hematologic and gastrointestinal effects. The incidence of the patients was 56% with mild nausea/vomiting,71% and 7% with grade Ⅰ / Ⅱ and Ⅲ leucopenia, and 38% with grade Ⅰ/Ⅱ hypodynamia and anepithymia. The 1-year overall survival,relapse-free survival and local control rates were 87% ,82% and 95%, respectively. Conclusions Postoperative chemoradiation for patients with locally advanced gastric cancer is tolerable. Our study shows the advantage of post-operative chemoradiation for local control. However,further prospective randomized trial is needed to validate the efficacy.
