Roles of transforming growth factor-β1 gene polymorphisms in severe acute respiratory syndrome and the interstitial lung fibrosis after recovered
- VernacularTitle:转化生长因子-β1基因多态性在严重急性呼吸综合征发生及愈后肺间质纤维化中的作用
- Author:
Maoti WEI
;
Yi HAN
;
Li HE
;
Keju ZHANG
;
Zhen YANG
;
Wuli HUI
;
Yilan HU
;
Shixin WANG
- Publication Type:Journal Article
- Keywords:
Transforming growth factor beta;
Genes;
Polymorphism,genetic;
Severe acute respiratory syndrome;
Pulmonary fibrosis
- From:
Chinese Journal of Infectious Diseases
2008;26(3):172-176
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the roles of transforming growth factor(TGF)-β1 gene polymorphisms in severe acute respiratory syndrome-coronavirus(SARS-CoV)infection and the interstitial lung fibrosis after recovered.Methods Sixty-five recovered SARS patients,37 health care workers and 66 healthy controls were enrolled in this case-case study.The association between genetic polymorphisms of TG F-β1 and suscept ibility to SARS or interstitial lung changes after SARS reco,vered was carried out.Polymerase chain reaction-sequencing based typing(PCR-SBT)method was used to determine the polymorphisms of TGF-β1 gene at locus+869 and+915.Data were analyzed using t test and chi square test.Results There was no significant association of TGF+β1 gene polymorphisms at locus+869 and+915 in recovered SARS patients,health care workers and heahhy controls.And gene linkage of this two loci was not related with SARS-CoV susceptibility.Furthermore,no association between interstitial lung changes in recovered SARS palients and TGF-β1 gene polymorphisms or genetic linkage of this two loci.Conclusions It may not be related between TGFβ1 gene polymorphisms at locus+869 and+915 and SARS-CoV susceptibility.And interstitial lung changes in recovered SARS patients may not be influenced by TGF-β1 gene polymorphisms.
