An analysis On 78 cases of contact allergy to topical corticosteroids
- VernacularTitle:外用糖皮质激素接触过敏78例分析
- Author:
Xin SHI
;
Xiaodong SUN
;
Sunping JI
;
Zhihua YAN
- Publication Type:Journal Article
- Keywords:
Glucocorticoids;
Hypersensitivity;
Patch tests;
Administration,cutaneous
- From:
Chinese Journal of Dermatology
2008;41(4):223-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective To update the knowledge of contact allergy to topical corticosteroids.Methods A total Of 1,822 patients,who Sufiered from inflammatory skin disorders but did not respond well to topical corticosteroids,were enrolled into this study.Patch test was performed on these subjects with corticosteroid allergens,following the standardized rocedures ecommended by the International Contact Dermatitis Research Group(ICDRG).Results Of all patients,78(4.28%)had positive patch test.Among the 78 patients,33 were males,45 females,and most were young or middle-aged.During 96-168 hours after the removal of patches,positive results Were observed in 42.31%(33/78)of the patients.Twenty eight patients had anaphy lactic reaction induced by hydrocortisone butyrate,25 by dexamethasone sodium phosphate,and 17 by triam cinolone acetonide.A correlation Between sensitizing glucocorticoids detected by patch testing and adminis trated drugs in clinic was found in 74 cases.ConclusionsContact allergy caused by topical corticosteroids is not rare,and more attention should be paid to this issue in the treatment of inflammatory skin disorders.
