Effects of angiotensin-converting enzyme inhibitor on microcirculation of peripheral nerve in diabetic rats
- VernacularTitle:血管紧张素转换酶抑制剂对糖尿病大鼠周围神经微循环的影响
- Author:
Liping HAN
;
Demin YU
;
Yun XIE
- Publication Type:Journal Article
- Keywords:
Angiotensin-converting enzyme inhibitors/PD;
Diabetes mellitus/BL;
Peripheral nerves/BS
- From:
Journal of Chinese Physician
2008;10(3):320-323
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate prevention and therapy effects of ACEI on peripheral nerve in the earlier stage of diabetic rats and the influence on microcirculation of experimental DPN.Methods Diabetes was induced by STZ.After 8 weeks of prevention or therapy treatment.the effects of lisinopril on function and structure of diabetic peripheral nerve were observed,the NO,NOS level in plasma and capillary density of sciatic nerve were determined.Results Lisinopril prevention and therapy treatment improved nerve conduction velocity,ameliorated morphology abnormalities in nerve fiber and capillary at different degrees.The NO level and capillary density of endoneurium were increased. Conclusions ACE inhibitors may exert neuroprotective effect through improving abnormality of microcirculation.
