The comparative study of perfusion MR imaging in primary central nervous system lymphomas and high grade astrocytomas
- VernacularTitle:中枢神经系统原发淋巴瘤和高级别星形细胞瘤MR灌注成像的对比研究
- Author:
Biao HUANG
;
Changhong LIANG
;
Hongjun LIU
;
Guangyi WANG
;
Zhenggen ZHOU
- Publication Type:Journal Article
- Keywords:
Astrocytoma;
Lymphoma;
Magnetic resonance imaging;
Diagnosis,differential
- From:
Chinese Journal of Radiology
2008;(3):276-280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of perfusion MR imaging in differential diagnosis between primary central nervous system lymphomas(PCNSL)and high grade astrocytomas.Methods Twelve patients with PCNSL and 23 patients with high grade astrocytomas were preoperatively examined using a 1.5T MR unit.Routine MR sequences were performed followed by dynamic susceptibility contrastenhanced MR perfusion imaging.The perfusion color images and the time-signal intensity curves of the two tumor groups were compared.The relative cerebral blood volume(rCBV)within the tumor parenchyma was measured and the data were analyzed with unpaired Student's t-test.Results The rCBVs within the tumor parenchyma of the PCNSL and high grade astrocytomas were 1.78±0.5 1 and 3.87±0.87 respectively.The rCBV in the PCNSL was significantly lower than that of the high grade astrocytoma(P＜0.05).When the time-signal intensity curves were compared,the PCNSL showed a trend towards the baseline after the first pass and the curves even overshot above the baseline in 7 out of 12 cases,whereas the high grade astrocytoma showed a trend to be close to the baseline but couldn't return to the baseline completely.Conclusion The MR perfusion imaging can be very useful in distinguishing the PCNSL from high grade astrocytomas.
