Rho/ROCK and Neurological Diseases
- VernacularTitle:Rho/ROCK与神经系统疾病
- Author:
Hua TANG
;
Heqing ZHAO
- Publication Type:Journal Article
- Keywords:
Rho kinase;
cerebrovascular disease;
axonal regeneration
- From:
International Journal of Cerebrovascular Diseases
2008;16(3):233-236
- CountryChina
- Language:Chinese
-
Abstract:
As a molecular switch,Rho can be transformed between the inactive GDP-bound form and the active GTP-bound form,transfering signals to downstream effector Rho kinase (ROCK),mediating specific biological effects,and participating in various neurological diseases, such as the pathological processes of ischemic stroke,cerebral vasospasm,and axonal regeneration after spinal cord injury.The application of ROCK inhibitor in the treatment of neurological diseases has achieved satisfactory effect.Rho/ROCK is expected to become a novel therapeutic target.
