Effects of cromolyn sodium on forebrain ischemia-reperfusion injury in gerbils
- VernacularTitle:色甘酸钠对沙土鼠前脑缺血再灌注损伤的影响
- Author:
Xiaoliang GAN
;
Ning SHEN
;
Nan CHENG
;
Ziqing HEI
- Publication Type:Journal Article
- Keywords:
Cromolyn sodium;
Cerebral ischemia;
Brain
- From:
Chinese Journal of Anesthesiology
2008;28(4):372-374
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of cromolyn sodium(CS)on forebrain ischemiareperfusion injury in gerbils.Methods Twenty-four male gerbils weishing 55-70 g were randomly divided into 3 groups(n=8 each):group Ⅰ sham operation;groupⅡ I/R and group Ⅲ CS 50 mg/kg+I/R.Forebrain ischemia was produced by occlusion of bilateral common carotid arteries for 10 min and confirmed by isoelectricity of EEG. CS was injected via lingual vein at 0 and 1 h of reperfusion.All the animals were killed at 2 h of reperfusion for determination of cerebral cortex injury score,cerebral water content[(wet weight-dry weight)/wet weight×100%],cerebral MDA content,SOD activity and histamine content.Results The cerebral cortex injury 8core,cerebral water content, MDA content and histamine content were significantly increased while SOD activity was signiiieantly decreased in I/R group(Ⅱ)aa compared with sham operation group(Ⅰ)(P＜0.05 or 0.01).CS significantly attenuated the I/R-induced changes(P＜0.05 or 0.01).Conclusion CS can attenuate the forebrain ischemia-reperfusion injury by reducing histamine and oxidative response.
