Brain activation during associative learning and memory in healthy volunteers:a functional magnetic resonance imaging
- VernacularTitle:联想学习记忆的脑功能磁共振成像
- Author:
Jinlong ZHENG
;
Siyun SHU
;
Songhao LIU
;
Yongming WU
;
Zhouyi GUO
;
Xinmin BAO
;
Zengqiang ZHANG
;
Hanzhang MA
- Publication Type:Journal Article
- Keywords:
Association learning;
Memory;
Magnetic resonance imaging;
Corpus striatum
- From:
Chinese Journal of Neurology
2008;41(4):230-233
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine whether the marginal division of the striatum(MrD)is involved in the associative learning and memory function of human brain with the help of functional magnetic resonance imaging(fMRI)technique.Methods Sixteen right-handed normal volunteers participated in a test of paired-word associative learning and memory,while the fMRI data were recorded.Control tasks were performed for the block-design.Statistcs parameter mapping 99 was used to analyze the data and to obtain the activated brain regions.Results When the threshold was set as P＜0.005.using a one-sample T-test,the left occipital lobe and the superior and middle gyrus of the left frontal lobe were activated remarkably during the encoding process of the paired-word associative learning and memory task,with the maximum intensity T value being 13.87 and 9.36.respectively.The left MrD was also obviously activated during this stage(T value was 5.46).But during the retrieval process,the left parietal lobe was prominently activated(T value was 8.73).Conclusion The resuhs of this study reveal that the subcortical structures such as MrD as well as the cerebral cortex are involved in the associative learning and memory of paired-word in human brain.
