The application of HA330-Ⅱ microporous resin plasma adsorption in the treatment of chronic severe hepatitis
- VernacularTitle:HA330-Ⅱ中性大孔树脂血浆吸附在重度慢性肝炎救治中的应用
- Author:
Xiaobing HU
;
Hongbo GAO
;
Minger LIAO
;
Minru HE
- Publication Type:Journal Article
- Keywords:
Ion exchange resins;
Liver,artificial;
Hepatitis,chronic
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(3):380-382
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of the study is to discuss the application value of HA330-Ⅱ microporous resin plasma adsorption in liver support and the treatment of complications of chronic severe hepatitis.Methods The treatment group has 41 patients of chronic severe hepatitis B,which were treated for 3 times by HA330-Ⅱ microporous resin plasma adsorption.We compared the improvement of symptom,the fadeamay and rebound of icterus,the change of hepatic encepllalOpathy and brain oedema,the change of blood routine test,blood ammonia level,blood-gas analyzing result,cruor index,inflammatory factors(IL-1b,IL-6,IL-8,TNF-α,etc.),side effects,etc.The control group has 37 patients of the same type.Results HA330-Ⅱ microporous resin plasma adsorptioin is partly effective for the improvement of symptom,improvernent rate 43.9%,and without new discomfort due to the treatment. It obtains some extent fadeaway of icterus which has a low rebound,reduce TBiL(17.83±3.65)% and there be no statistics difference of rebound.It lowers the blood ammonia level and improves the hepatic encephalopathy and brain oedema.It absorbs cytokine IL-8.Atthough it has some extent effect to albunfin,blood paltelet,haemoglobin.Conclusion HA330-Ⅱ microporous resin plasma adsorption has good application value in the treatment of chronic severe hepatitis B.It is a new treatment choice of severe hepatitis.
