A clinical study of 103 idiopathic thrombocytopenic purpura
- VernacularTitle:特发性血小板减少性紫癜103例患者的临床分析
- Author:
Yun FAN
;
Naibai CHANG
;
Baoli XING
;
Yuanming LI
;
Lei PEI
;
Jiangtao LI
- Publication Type:Journal Article
- Keywords:
Purpura,thrombocytopenic,idiopathic;
Immunosuppressive agents;
Drug therapy
- From:
Chinese Journal of Internal Medicine
2008;47(4):313-315
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence by age,response to different therapies and outcome in newly diagnosed idiopathic thrombocytopenic purpura(ITP). Methods ITP patients who were hospitalized from July 1992 to December 2006 and followed uD with telephone were retrospectively analyzed.Results 103 patients with ITP were investigated. The time of follow-up was between 2 months to 15years.to adrenocorticosteroid and 4 patients under going splenectomy achieved a normal platelet count. In those immunosuppressive agents:including vincristine,cyclophosphamide,azathioprine and cyclosporin A(CsA)used in the present series. CsA was shown to be more effective. It could increase the platelet count when given together with prednisolone,the effective rate was 81.3%(26/32). Severe side effects like kiney function failure were not found in CsA treated patients so the use of geug in ITP would be recommended.There were 2,1 and 1 ITP patients progressing respectively to Sjogren's syndrome,systemic lupus erythematosus and lymphoma. 7 patients died,1 patient died of cerebral bleeding,2 brain infarction,3 malignant neoplasm and 1 nephrosis The refractory rate of ITP is 17.2%(10/58). Conclusions The morbidity in older people is high. The mortal bleeding in ITP is low. Treatment should be tailored to the individual patient.
