Effect of metformin on endothelial function in women with polycystic ovary syndrome
- VernacularTitle:多囊卵巢综合征患者用二甲双胍治疗后血管内皮功能变化
- Author:
Zheng ZHENG
;
Huilan LUO
;
Duo XU
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Metformin;
Endothelium,vascular
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(3):412-413
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of metformin on endothelial function in women with polycystic ovary syndrome.Methods 30 women with PCOS were enrolled.Metformin were taken 500mg three times a day contiguously using 3 months.Before and after treatment flow-mediated EDD function and other clinical metabolic parameters,such as serum endothelin-1,insulin,testosterone,glucose,lipid,waist-hip ratio,body mass index.Results After the treatment of metformin in study group,WHR,BMI and endothelin-1 have no significant difference compared with before the treatment(P＞0.05).But the changes of brachial artery diameter and HDL were increasing and LH/FSH,T,insulin,HOMA-IR,TG and LDL were significant decreasing after the treatment in study group compared with before the treatment(P＜0.05).There was no significant difference in WHR,BMI,endothelin-1,the changes of brachial artery diameter,LH/FSH,T,insulin,HOMA-IR,TG and LDL between the study group after the treatment with the control group.Meanwhile,HDL were significant increasing in the study group after the treatment compared with the control group(P＜0.05).Conclusion There are impaired endothelial function and insulin resistance in women with PCOS.After the treatment with metrormin,the endothelial function and insulin resistance could be improved.
