Influence of Nictinamide on endotheline in patients with pulmonary arterial hypertension
- VernacularTitle:钾通道开放剂烟酰胺对肺动脉高压血浆内皮素1影响的临床观察
- Author:
Yiqian ZHOU
;
Jinlan LI
;
Surong ZHANG
- Publication Type:Journal Article
- Keywords:
Nicfinamide;
Pulmonary arterial hypertension;
Endotheline 1
- From:
Clinical Medicine of China
2008;24(4):316-317
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of Nictinamide on the endotheline(ET-1)in patienta with pulmonary arterial hypertension(PAH).Methods 66 cases of PAH were divided randomly into two groups (n=33for each):the Nictinamide treatment group and the control group.The changes of endotheline were compared before and after treatment.Results After treatment serum endotheline was significantly lower in the treatment group(P＜0.01),but there was no difference in the control group before and aftertreatment(P＞0.05).The significant difference was observed between treatment group and control group(P＜0.01).Conclusion Nictinamide will reduce the level of endothellne and confers some degree therapeutic and preventive value for PAH.
