Effect of Hypoxia-Inducible Factor-1α on Early Formation of Brain Edema During Intracerebral Hemorrhage
- VernacularTitle:缺氧诱导因子-1α在脑出血早期脑水肿形成中的作用
- Author:
Qingxin LIU
;
Jinbo CHEN
;
Yuhong ZHU
;
Heliang ZHANG
- Publication Type:Journal Article
- Keywords:
hypoxia-inducible factor-1α;
vascular endothelial growth factor;
intracerebral hemorrhage;
brain edema
- From:
International Journal of Cerebrovascular Diseases
2008;16(3):181-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect and mechanism of hypoxia-inducible factor-1α (HIF-1α)in perihematomal brain tissue on the early formation of edema in patients with hyper-tensive intracerebral hemorrhage.Methods:The perihematomal brain tissue in 32 patients with hypertensive intracerebral hemorrhage were treated with hematoma evacuation.The expressions of HIF-1α and vascular endothelial growth factor(VEGF)were measured by immunohistochem- istry staining technique.The volume of perihematomal edema was determined on the basis of reoperative head CT scan.The results of staining and the volume of edema were analyzed by using double-blind method.Resets:Neuron and vascular endothelial cell swelling were observed 4 hours after cerebral hemorrhage,and the scattered HIF-1α positive neurons were visible.The expressions of HIF-1α reached the peak(at 24 to 48 hours,and went on high expressions at 49 to 72 hours.There was significant difference as compared with the normal brain tissue(P＜0.01). There were positive correlations between the expressions of HIF-1α and VEGF (r=0.72,t=6.37,P＜0.01)and the volume of brain edema(r=0.64,t=4.56,P＜0.01).Conclusions: The expression of HIF-1α in perihematomal brain tissue of hypertensive cerebral hemorrhage iS associated with the early formation of cerebral edema.HIF-1α may accelerate the formation of brain edema by inducing and regulating the expression of VEGF.
