Effect of blocking 4-1BB/4-1BBL on the proliferation of T cell and the expression of Th1 and Th2 cytokines in T cells from patients with systemic lupus erythematosus
- VernacularTitle:阻断4-1BB/4-1BBL通路对系统性红斑狼疮T淋巴细胞增殖和细胞因子分泌的影响
- Author:
Rong ZHANG
;
Xiaofei WANG
;
Lijuan ZHAO
;
Weiguo XIAO
;
Yi JIANG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
4-1BB;
anti-4-1BB McAb;
Interferon type Ⅱ:Interleukin-4
- From:
Chinese Journal of Rheumatology
2008;12(4):222-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of T lymphocyte proliferation,Th1 and Th2 cytokines on T cells from systemic lupus erythematosus (SLE)patients by blocking 4-1BB/4-1BBL.Methods The proliferation of T cells from 30 SLE patients and 20 normal controls was detected by MTT and the levels of patients stimulated with anti-CD3 McAb were significantly higher than those of T cells without stimulation(P＜IFN-γand IL-4 in SLE were significantly higher than those of normal controls(P＜0.01).There were more ex-pression of IFN-γ and IL-4 in supernatant of T cells from SLE after stimulated with anti-CD3 McAb(P＜0.01).However,the production of IFN-γ and IL-4 was inhibited by anti-4-1BB McAb(P＜O.05),and especially the level of IL-4 was markedly decreased.Conclusion Blocking 4-1BB/4-IBBL can significantlv inhibit the abnormal activation of T cells and the secretion of Thl and Th2 cytokines of SLE.
