Effect of acute hypervolemic hemodilution on the onset and recovery of muscle relaxation induced by vecuronium
- VernacularTitle:急性高容量血液稀释对全麻患者维库溴铵肌松起效和恢复的影响
- Author:
Hong ZHENG
;
Fei XUAN
;
Yan XUAN
- Publication Type:Journal Article
- Keywords:
Hemodilution;
Vecuronium;
Neuromuscular blockade
- From:
Chinese Journal of Anesthesiology
2008;28(4):349-352
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of acute hypervolemic hemodilution(AHHD)on the onset and recovery of muscle relaxation induced by vecuronium.Methods Thirty-two ASA Ⅰ orⅡpatients undergoing elective surgery under general anesthesia were randomly divided into 2 groups(n=16 each):control group and AHHD group.A loading dose of vecuronium 0.1 mg/kg Was given at 10 min after AHHD following tracheal intubatiom The muscular relaxation was maintained at Tl/Tc 5% to 15% by supplement with intravenous vecuroninm.Blood samples were taken at various times during AHHD for chemical analysis.The onset and recovery time of muscular relaxation were recorded.Results Compared with control group ,Hct,Hb and the concentration of TP and Alb were decreased,and the onset and recovery time of vecuronium were shortened in group AHHD(P＜0.05).Conclusion Acute hypervolemic hemodihtion can shorten the onset and recovery of muscle relaxation of vecuronium in patients under general anethesia.
