The value of APACHE Ⅱ to predict the outcome of the patients with severe neurologic diseases
- VernacularTitle:急性生理学和慢性健康状况评估Ⅱ预测危重神经疾病的预后
- Author:
Yingying SU
;
Hongliang LI
;
Guihua CAO
;
Dongyu WANG
;
Jianghong LIU
;
Xianling WANG
- Publication Type:Journal Article
- Keywords:
Nerous system diseases;
APACHE;
Prognosis;
Intensive care
- From:
Chinese Journal of Neurology
2008;41(4):258-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the reliability of acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)to evaluate the severity of the neurologic diseases and its accuracy to predict the outcome of patients with these diseases.Metllods Four hundred and four consecutive patients with severe neurologic diseases between 2005 and 2006 were enrolled to obtain the APACHE Ⅱ scores at 0.24,48,72 h after admission to neurointensive care unit.Results The APACHE Ⅱ scores were positively associated with the outcome of the patients with severe neurologic diseases.The higher score corresponded with the higher mortality rate.The areas under the receiver operating characteristic curves of APACHE Ⅱ to predict the outcome was 0.866(95% CI 0.824 to 0.907.P=0.000).The optimal cutoff of APACHE Ⅱ scores to predict the outcome was 17 scores with the sensitivity of 76.7%and the specificity of 78.7%.The predictive chance that was mostly associated with the outcome was 72 h after admission in logistic regression model (x2=137.345,P=0.000,correct class%=85%).The factors that were the most statistically associated with the outcome in the 14 parameters of APACHE Ⅱ were GCS score,heart rate,serum creatinine,body temperature and WBC count.Conelusion APACHE Ⅱ favorably reflects the severity of the neurologic diseases and reliably and accurately predicts the prognosis of the patients.
