Clinical and histopathologic analysis of 7 cases of mucormycosis
- VernacularTitle:毛霉病七例临床与病理分析
- Author:
Jia CHEN
;
Xuesi ZENG
;
Yiqun JIANG
;
Yanning XUE
;
Lixiong GU
;
Hao CHEN
;
Amei LI
;
Honggui SANG
;
Xu YAO
;
Suquan HU
;
Guixia LU
;
Zehu LIU
;
Liuqing CHEN
;
Jianfang SUN
- Publication Type:Journal Article
- Keywords:
Mucormycosis;
Mucor;
Pathology，clinical
- From:
Chinese Journal of Dermatology
2008;41(4):217-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the clinical manifestations,prognosis and histopathological findings of mucormycosis.Methods The clinical data on and pathological findings from 7 cases of mucormycosis confirmed by fungal culture in the institute from 1989 to 2006 were analyzed retrospectively.Results There was 1 case of hinocerebral mucormycosis and 6 cases of cutaneous mucormycosis,among them,2 were mucormycotic necrotizing fasciitis (MNF).The condition of patients with rhinocerebral mucormycosis or MNF aggravated rapidly and all the 3 patients died from mucormycosis. Histopathological examination showed mixed infiltrates of inflammatory cells as well as necrosis and angioin vasion.On the contrary,the condition of the remaining 4 patients with cutanesus mucormycosis,who presented mainly with indurated erythematous patch,progressed slowly,and 2 patients were cured.Histologically,the lesions were characterized by granulbmatous infiltration with a few hyphae;no typical angioinva sion phenomenon was noted.There was no evidence of perineural invasion with hyphae in any of the 7 cases.ConclusionIn patients with mucormycosis,histopathological findings characterized by mixed infiltrates of inflammatory cells,numerous hyphae and typical angioinvasion phenomenon may herald a poor prognosis.
