The value of anti-deiminated recombinant rat filaggrin antibody in predicting disease activity of rheumatoid arthritis
- VernacularTitle:脱亚胺基重组鼠聚微丝蛋白抗体在类风湿关节炎活动性评价中的意义
- Author:
Zhiwei CHEN
;
Junxia YANG
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Anti deiminated recombinant rat filaggrin antibody
- From:
Chinese Journal of Rheumatology
2008;12(4):261-263
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of deiminated recombinant rat filaggrin antibodies (ArFA)in predicting the activity of rheumatoid arthritis (RA).Methods ArFA was detected with enzyme linked immunosorbent assay(ELISA)in 61 patients with active RA and 48 patients with inactive RA.The ESR,CRP,RF were measured,while tender ioint count,swollen joint count and patient's general assessment were recorded.The level of ArFA in 20 RA patients was measured before and after treatment.Results The level of ArFA in patients with active RA was higher compared with patients with inactive RA [(130±35)U/L cs(66±25)U/L,P=0.004 ],the level of ArFA after treatment was reduced (79.8 U/ml vs 118.2 U/ml,P=0.000).Conclusion The level of ArFA can predict disease activity of RA.
