Matrix Metalloproteinases and Atherosclerotic Plaques
- VernacularTitle:基质金属蛋白酶与动脉粥样硬化斑块
- Author:
Jinfeng ZHANG
;
Guorong LIU
;
Jingfen ZHANG
;
Ruiming LI
- Publication Type:Journal Article
- Keywords:
matrix metalloproteinase;
atherosclerotic plaque;
extracellular matrix
- From:
International Journal of Cerebrovascular Diseases
2008;16(2):141-144
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinases (MMPs) degrade extracellular matrix,participate in the atherosclerosis (As) formation and plaque rupture.They are associated with the stability of plaque.Tissue inhibitor of metalloproteinase (TIMP) is a specific natural MMP inhibitor.The disequilibrium between MMPs and TIMP is closely associated with the formation and development of AS.Therefore,it is a new approach for the prevention and treatment of cardiocerebrovascular diseases by regulating the equilibration between MMPs and TIMP, delaying the development of AS and preventing plaque rupture.
