Relationship between polymorphism of peroxisome proliferator activated receptor gamma gene and osteoporosis in elderly male
- VernacularTitle:过氧化物酶体增殖物激活受体γ基因多态性与老年男性骨质疏松的相关性
- Author:
Xinfu LIN
;
Gang CHEN
;
Jixing LIANG
;
Lixiang LIN
;
Xiaoli SHEN
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Bone density;
PPAR gamma;
Polymorphism,single nucleotide
- From:
Chinese Journal of Geriatrics
2008;27(4):266-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the single nucleotide polymorphisms of exon 6 C161→T of peroxisome proliferators activated receptor γ(PPART)gene and osteoporosis in elderly male. Methods Polymerase chain reaction restriction-fragment length polymorphism(PCR-RFLP)was used to analyze the gene frequency distribution in the groups of nonosteoporosis and osteoporosis in elderly male.Bone mineral density of lumbar and hip(neck of femur,greater trochanter,Ward's triangle)were measured by dual energy X-ray absorptiometry.Serum osteocalcin level was measured by enzyme-labeled immunosorbent assay(ELISA). Results The exon 6 of PPARγ had 3 genotypes(CC,CT and TT).The frequency of T allele in osteoporosis was higher than that in non-osteoporosis.Compared with the control group,serum bone glaprotein level and bone mineral density was lower in osteoporosis group.The bone mineral density in the genotype of CT and TT groups were lower than that in the genotype of CC group. Conclusions The study shows that the single nucleotide polymorphisms of 6th exons of PPARγ may relate to osteoporosis in elderly male.T allele of PPARγ may be a predisposing factor of osteoporosis in elderly male.PPARγmay be a candidate gene of osteoporosis in elderly males.
