Methylenetetrahydrofolate reductase C677T polymorphism for primary hyperuricemia and gouty arthritis
- VernacularTitle:原发性高尿酸血症和痛风性关节炎患者亚甲基四氢叶酸还原酶基因C677T多态性的检测
- Author:
Qiaohui ZHANG
;
Jie LIU
- Publication Type:Journal Article
- Keywords:
Hyperuricemia;
Methylenetetrahydrofolate reductase
- From:
Chinese Journal of General Practitioners
2008;7(4):259-260
- CountryChina
- Language:Chinese
-
Abstract:
The relation of methylenetetrahydrofolate(MTHFR)reductase C677T polymorphism with primary hyperuricemia and gouty arthritis was observed in People's Hospital of Shanxi Province.MTHFR reductase C677T pdymorphism in 195 subjects was examined by PCR-restriction fragment length polymorphism.The results showed that MTHFR gene mutation might be a risk factor for primary hyperuricemia.However,C677T polymorphism of the MTHFR gene was not related to the development of gouty arthritis.
