The correlation of plasma osteopontin level with disease activity and organ damage in systemic lupus erythematosus patients
- VernacularTitle:系统性红斑狼疮患者血浆骨桥蛋白水平与疾病活动性及脏器损害的相关性研究
- Author:
Xingrui LI
;
Jianhua XU
;
Xiaomei ZHOU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Osteopontin;
Plasma
- From:
Chinese Journal of Rheumatology
2008;12(4):242-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the plasma level of osteopontin (OPN)in systemie lupus erythematosus (SLE) patients,and its correlation with disease activity as well as organ damage was analyzed.Methods The plasma level of osteopontin was measured by enzyme-linked immunosorbent assay in 68 SLE patients and 36 healthy controls.Results The plasma level of OPN was significantly higher in SLE Datients than in healthy control group(P＜0.01).In SLE patients,the plasma OPN level was significantly higher in patients with renal damage than in patients without renal damage(P＜0.01).Patients with lung interstitial disease and gastrointestinal tract involvement,their plasma level of OPN was significantly higher than those of patients with inactive lupus (P＜0.01).The plasma level of OPN correlated positivelv and significantly with SLEDAI score(r=O.523,P＜0.001)and 24-hour urine protein excretion(r=0.403,P=0.001),but negativelycorrelated with serum C3 level (r=-0.398,P=0.001).There was no correlation between the Dlasma level of OPN and anti-dsDNA antibody,Sm antibody,erythrocyte sedimentation rate,serum IgG,IgA,IgM levels(P＞0.05 ). Conclusion OPN may be involved in the pathogenesis of SLE,and may be a potential marker for dis-ease activity and organ damage.
