Effect of hemodilution on brain tissue oxygen pressure and prognosis in patients with severe craniocerebral trauma
- VernacularTitle:血液稀释疗法对重型颅脑创伤患者脑组织氧分压及预后的影响
- Author:
Qiusheng ZHANG
;
Weiping LI
;
Guodong HUANG
;
Shijie LIANG
;
Meng ZHANG
;
Yongzhong GAO
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Hemodilution;
Oxygen pressure,brain tissue
- From:
Chinese Journal of Trauma
2008;24(4):249-252
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effect of hemodilution on brain tissue oxygen pressure and prognosis in patients with severe craniocerebral trauma. Methods A total of 42 cases of severe craniocerebral trauma were randomized divided into two groups, ie, control group and treatment group, to observe the changes of brain tissue oxygen pressure ( PbtO2 ) , hematocrit (HCT) and 6-month Glasgow outcome scale (COS) after injury. Then, PbtO2, HCT and GOS were compared between two groups. Restilts ( 1 ) There was a positive correlation between PbtO2 and HCT when HCT was lower than 0.25( r =0. 732 ,P ＜0. 001 ) in the treatment group; while a negative correlation was found between PbtO2 and HCT when HCT was higher than 0.25(r = - 0. 698 ,P＜0. 001 ). (2) Compared with control group, the index of brain tissue oxygen in treatment group was obviously higher ( t = 2.27, P = 0. 029 ) , with better prognosis (X2= 5.09, P ＜ 0.05 ). Conclusion Hemodilution can significantly increase brain tissue oxygen supply and improve the prognosis of cases of severe craniocerebral trauma.
