Expression of relaxin receptor in placental tissues of normal pregnancy and pre-eclampsia
- VernacularTitle:子痫前期患者胎盘组织中松弛素受体的表达
- Author:
Yongqing WANG
;
Jun LI
;
Zi YANG
- Publication Type:Journal Article
- Keywords:
Pre-eclampsia;
Placenta;
Receptors,G-protein-coupled;
Receptors,peptide
- From:
Chinese Journal of Obstetrics and Gynecology
2008;43(4):269-271
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the location and level of relaxin receptor in placenta tissues of preeclampsia and normal pregnancy,and the relationship of relaxin receptor with pre-eclampsia.Methods Twenty-six placenta tissue samples from pregnant women with severe preeclampsia(study group),and 20samples from normal pregnancies(control group)were obtained.We detected the expression of relaxin receptor by immunohistochemistry and the expression of relaxin receptor mRNA by RT-PCR.Results In the placenta of control and preeclampsia groups,the leucine-rich repeat-containing G protein-coupled receptor(LGR7)was positively expressed.Relaxin receptor was located in the membrane of trophoblast cells.There were both strong signals on cytotrophoblastic cells and syneytiotrophoblast.The level of relaxin receptor in the control group was 0.912 ±0.003.and 0.625±0.037 in the preeclampsia group.Thedifference between the two groups was obvious(P＜0.01).In the control group,the level of relaxin receptor mRNA was 0.776±0.021;in the preeclampsia group,it was 0.393±0.075.The difference was obvious(P＜0.01).Conclusion Decrease in the expression of relaxin receptor at placenta is related with the occurrence and development of preeclampsia.
