Association of Chlamydophila pneumoniae, Cytomegalovirus, Helicobacter pylori and HIV Infections with Myocardial Infarction.
- Author:
Woon Bo HEO
1
;
Young Kyung KIM
;
Sang Jin EUN
;
Jae Ki RYU
;
Won Kil LEE
Author Information
1. Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu, Korea. leewk@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Myocardial infarction;
Chlamydophila pneumoniae;
Cytomegalovirus;
Helicobacter pylori;
HIV;
Coronary artery disease;
Risk factors
- MeSH:
Antibodies;
C-Reactive Protein;
Chlamydial Pneumonia*;
Chlamydophila pneumoniae*;
Chlamydophila*;
Coronary Artery Disease;
Cytomegalovirus*;
Enzyme-Linked Immunosorbent Assay;
Helicobacter pylori*;
Helicobacter*;
HIV Infections*;
HIV*;
Immunoglobulin G;
Inflammation;
Myocardial Infarction*;
Odds Ratio;
Risk Factors
- From:Korean Journal of Clinical Microbiology
2005;8(1):41-46
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: There is some evidence linking the infections with common organisms such as Chlamydophila pneumoniae, cytomegalovirus (CMV), Helicobacter pylori and HIV to myocardial infarction (MI). We had performed a serologic study to assess whether C.pneumoniae, CMV, H. pylori and HIV infections are associated with MI. METHODS: Serum samples were obtained from 54 cases of acute MI, 33 cases of old MI, and 60 normal controls. C-reactive protein (CRP) as an inflammation marker was measured and antibodies to C.pneumoniae, CMV, H.pylori and HIV were assayed by ELISA. Odds ratios (OR) were calculated against control group. RESULTS: CRP was significantly higher in the acute MI and old MI group. ORs of C.pneumoniae infection increased considerably in the acute MI (IgM 1.57, IgG 4.80) and old MI group (IgM 2.42, IgG 5.18). ORs of CMV infection were 3.30 in the acute MI and 5.12 in old MI group. ORs of H. pylori infection showed below 1 in the acute MI and old MI. Anti-HIV antibody showed all negative result in three groups, so OR could not be calculated. CONCLUSION: C.pneumoniae and CMV infections appear to be risk factors for MI.
