The relationship between NDRG1 gene and differentiation level and metastasis in prostate cancer
- VernacularTitle:人N-myc下游调节基因与前列腺癌分化程度及转移的关系
- Author:
Wen LI
;
Hong DU
;
Yanxiao LIANG
;
Guorong LIU
- Publication Type:Journal Article
- Keywords:
Proto-oncogene proteins c-myc;
Prostatic neoplasms;
Neoplasm metastasis
- From:
Journal of Chinese Physician
2008;10(4):457-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of NDRG1 and its relationship to differentiation level and metastasis in prostate cancer. Methods The expression NDRG1 was examined by immunohistochemistry LSAB method in 86 samples of prostate cancer and benigh prostate hyperplasia. Results The NDRG1 was shown to be highly expressed in 30(73.3%)of prostate cancer and 70.0%of benign prostate hyperplasia.There were no evident difference between prostate cancer and prestate hyperplasia(P＞0.05).The expression of NDRG1 was gradually reduction with the Gleason score from 2-4 to 5-7 to 8-10 in prostate cancer, which was statistical significance(P＜0.05).The expression of NDRG1 in lymph node or bone metastasis was significantly lower than that in no metastasis of prostate cancer. There was a negative correlation between the expression of NDRG1 and lymph node or bone metastasis. The age had no correlation with the expression of NDRG1(P＞0.05).Conclusion NDRG1 is involved in the genesis and development of prostate cancer, which may be related to the differentiation level of prostate cancer and serve as a useful marker for early diagnosis of cancer and metastasis.
