The significance of TFPI test in Pre-DIC state of rats
- VernacularTitle:组织因子途径抑制物对大鼠前DIC状态检测的意义
- Author:
Zhong YUAN
;
Xichun XIAO
;
Min YANG
- Publication Type:Journal Article
- Keywords:
Thromboplastin;
Disseminated intravascular coagulation
- From:
Journal of Chinese Physician
2008;10(4):487-488
- CountryChina
- Language:Chinese
-
Abstract:
Objective This pre-DIC rat models were constructed by injecting LPS in order to reveal the relationship and significance among tissue factor pathway inhibitor (TFPI),platelet, fibrinogen, prothrombin time and activated partial thromboplastin time. Methods Enzyme-labeled immunosorbent assay was used to detect blood plasma TFPI in pre-DIC state rats(n=16),DIC state rats(n=8)and health rats(n=8).Platelet, fibrinogen, prothrombin time and activated partial thromboplastin time in the same rat were detected. Results TFPI increased first(pre-DIC state)and then decreased(DIC state)in the blood plasma of rata, but the levels of TFPI were always higher than that in the normal state. Conclusions TFPI is more sensitive and accurate to monitor the pro-DIC state than routine examination, which is very useful in the early diagnosis of pre-DIC state.
