The frequency and clinical significance of CD4+CD25+ regulatory T cells in peripheral blood from elderly tumor patients
- VernacularTitle:老年肿瘤患者外周血CD4+CD25+调节性T细胞的检测及临床意义
- Author:
Huiping WANG
;
Haiou HONG
;
Qing LI
;
Aimei ZHANG
;
Xiucai XU
;
Cuiping ZHANG
;
Yuanyuan SHEN
;
Juan LU
;
Zhimin ZHAI
- Publication Type:Journal Article
- Keywords:
T-lymphocytes;
Immunity,cellular;
Tumor immunity
- From:
Chinese Journal of Geriatrics
2008;27(4):269-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between CD4+CD25+ regulatory T(T-Reg)ceils and the higher prevalence of tumor in elderly people. Methods The frequencies of T-Reg in peripheral blood from 64 health adults.52 healthy elderly people and 64 elderly cancer patients were determined by multi-color detection and multi-parameter flow cytometry.and the relationships among the 3 groups were analyzed and the correlation among CD4+CD25high,CD4+CD25+FoxP3+and CD4+CD25+CD127low were studied. Results Be gated on CD4+ lymphocytes,the reference ranges of CD4+CD25high T cells in the groups of health adults.healthy elderly people and elderly cancer patients were(1.390±0.412)%,(1.729±0.247)%and(2.150±O.769)%respectively,while CD4+CD25+FoxP3+ T cells were(1.1 80±0.343)%,(2.477±0.400)%and (4.980±2.177)%respectively,and CD4+CD25+CD127low T cells were(5.213±0.942)%,(6.186±1.196)%and(7.194±1.538)%respectively.There was the same change rule in CD4+CD25high,CD4+CD25+FoxP3+and CD4+CD25+CD127low T cells of the 3 groups.elderly cancer patients was at the highest.then was healthy elderly people,and the last was health adults.The 3 markers were positively correlated among 3 groups(all P＜0.05).There were gender difference in 3 groups of CD4+CD25high,CD4+CD25+FoxP3+ and CD4+CD25+CD127low T cells. Conclusions The percentages of CD4+CD25high are increased with age and its excessive accumulation is possibly correlated with immunosenescence and the tumor development.
