The Prevalence of Antimicrobial Resistance in Helicobacter pylori Isolated in Daejeon.
- Author:
Jongwook LEE
1
;
Sun Moon KIM
;
Euyi Hyeog IM
;
Young Woo CHOI
;
Yoon Mee KIM
;
Pum Soo KIM
;
Jae Hag LEE
Author Information
1. Department of Laboratory medicine, Keonyang University Hospital, Daejeon, Korea. lee4@kyuh.co.kr
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
Antimicrobial resistance;
Amoxicillin;
Metronidazole;
Clarithromycin
- MeSH:
Amoxicillin;
Anti-Bacterial Agents;
Clarithromycin;
Drug Resistance, Microbial;
Egg Yolk;
Endoscopy, Gastrointestinal;
Helicobacter pylori*;
Helicobacter*;
Humans;
Metronidazole;
Prevalence*;
Proton Pumps
- From:Korean Journal of Clinical Microbiology
2005;8(1):47-50
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The most commonly used regimen for the eradication of Helicobacter pylori is combination of a proton pump inhibitor, clarithromycin, and two other antibiotics, metronidazole and amoxicillin. The increase in resistance to antibiotics seems to result in a decrease in eradication efficacy for H.pylori. We investigated the prevalence of antibiotic resistance in H.pylori isolated in Daejeon area. METHODS: A total of 31 clinical isolates of H.pylori were collected from the patients who underwent upper gastrointestinal endoscopy in Keonyang University Hospital during the period from March to July 2004. Antibiotic susceptibility tests for metronidazole, amoxicillin, and clarithromycin were performed by the E test (AB Biodisk, Sweden) on an egg yolk medium containing triphenyltetrazolium. The resistance break points for amoxicillin, metronidazole, and clarithromycin were defined as 0.5 microgram/mL, 8 microgram/mL, 1 microgram/mL, respectively. RESULTS: Resistance to amoxicillin, metronidazole, and clarithromycin was detected in 7.4% (2/27), 25.8% (8/31), 3.6% (1/28), respectively. CONCLUSION: The resistance to amoxicillin and clarithromycin was uncommon in Daejeon area.
