Clinicopathological characteristics in hereditary nonpolyposis colorectal carcinoma-associated endometrial carcinoma
- VernacularTitle:遗传性非息肉性结直肠癌综合征相关性子宫内膜癌的临床病理特征
- Author:
Yingmei WANG
;
Yanbin ZHU
;
Fengxia XUE
;
Zengyou LIU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms,hereditary nonpolyposis;
Endometrial neoplasms;
Adenocarcinoma;
Prognosis
- From:
Chinese Journal of Obstetrics and Gynecology
2008;43(4):286-289
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study clinicopathological characteristics of hereditary nonpolyposis colorectal carcinoma(HNPCC)-associated endometrial carcinoma(EC).Methods Totally 421 EC patients admitted to General Hospital of Tianjin Medical University from 1981 to 2006 were divided into three groups:group A:sporadic EC;group B:familial aggregation of EC;group C:HNPCC-associated EC.Results HNPCC-associated EC accounted for 6.4%(27/421).Mean age at time of diagnosis was 49.7years in group C,earlier than 56.3 years in group A(P=0.004)and 55.2 years in group B(P=0.035).There were 33.3%(9/27)patients with multiple primary carcinomas in group C.It was higher than 14.3%(9/63)in group B and 5.1%(17/331)in group A respectively(P=0.038,P＜0.01).There was no difference among the three groups in histological type or menopausal status(P＞0.05).The numbers of patients with low grade EC in group C(70.4%,19/27)and group B(61.3%,38/62)were more than that in Group A(P=0.013,P=0.023).Prognosis for group C was better than that in group A(P=0.021),and 5-and 10-year survival rate in groups A,B and C was 80%,70%;88%,85%;and 96%,96%respectively.Conclusions Mean age at time of diagnosis is earlier in HNPCC-associated EC than that in sporadic EC;patients with HNPCC-associated EC are more frequently complicated with multiple primary carcinomas and of low grade;prognosis is better.
