The imitation release test of extra-body on sustained-released injection of microcapsule hydro-cortisone
- VernacularTitle:氢化泼尼松微胶囊缓释剂体外模拟释放试验研究
- Author:
Xiaoan SUN
;
Anli XU
;
Chang WANG
;
Deming XIE
- Publication Type:Journal Article
- Keywords:
Prednisone;
Capsule;
Delaye-action preparations
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(4):543-544
- CountryChina
- Language:Chinese
-
Abstract:
Objective By extra-body imitation release test with prolongation,medicines action on sustainedreleased injection of hydro-cortisone microeapsule was understood. Methods Making use of HPLC method was inspected to result of medicinal lower and die, solution. At the same time, the disaolvent course of microcapsule wall was observed by microscope and electron microscope. Results The release test at beginning 12 - 24 hours with rdease drugs measure was very lower-degree,along with the time more prolong in mierocapsule substance to contact of PBS solution(24～48h) was began disintegrate. The rdease of medicinal concentration also accompany with rising, the rising different concentration PBS solution from starting up to the highest as to general need 3～5 days and keep releasing for several days. Conclusion Sustained-released injection of hydrocortisone mierocapsule can be effectual action of prolongation released time in hind hydrocortisone.
