Correlation of hyperuricemia with cardiovascular and cerebrovascular diseases in type 2 diabetes mellitus
- VernacularTitle:高尿酸血症与糖尿病心脑血管并发症的关系
- Author:
Yunling HAO
;
Hongling WU
;
Libo CHEN
;
Changning ZHANG
- Publication Type:Journal Article
- Keywords:
Hyperurieemia;
Diabetes inellitus,type 2
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(4):562-563
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of hyperurieemia on cardiovascular and cerebrovaseular complications in type 2 diabetes mellitus(T2DM). Methods According to the level of blood uric acid,430 patients with T2DM were divided into hyperuricemia group and non-hyperurieemia group, the differences of uric acid(UA) ,creatine(Cr) ,total cholesterol(TC) ,triglyeride(TG) ,fasting blood glucose(FBG) ,glycosylated hemoglobin(HbA1c) and body mass index(BMI) were compared,and the occurrences of coronary heart disease, hypertension and acute cerebrovascular accidence were observed. Results The FBG and HbAIc were not significantly different between the two groups(P＞0.05). The BMI ,TG,TC and Cr in the hyperurieemia group were significantly higher than those in the non-hyperuricemia group(P＜0.05 ). The incidence rates of coronary heart disease, hypertension and acute cerebrovascular diseases in the hyperuricemia group were also significantly higher than those in the non-hyperuricemia group (P＜0.05 ). Conclusion Hyperuricemia is obviously correlated with obesity and blood lipid abnormalities. Hyperurieemia can aggravate the metabolic disturbances,and can accelerate the occurrence and development of cardiovascular and eerebrovascular diseases in the patients with T2DM.
