Relationship between T cell subsets and hyporesponsiveness to erythropoietin in maintenance hemodialysis patients
- VernacularTitle:维持性血液透析对T细胞亚群与红细胞生成素低反应性的影响
- Author:
Lianyuan LU
;
Lei WANG
- Publication Type:Journal Article
- Keywords:
Hemodia filtration;
T-lymphocyte subsets;
Erythropoietin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(4):627-628
- CountryChina
- Language:Chinese
-
Abstract:
Objective One hypothesis is that patients with uraemia showing hyporesponsiveness to rHuEPO may have enhanced levels of immune activation causing increased rdease of inflammatory cytokines. To study the effects of chronic inflammation on the hyporesponsiveness to rHuEPO and its possible mechanisms, T cell phenotypes using flow cytometry and the relationship between these changes were detected. Methods 40 patients with MHD and 20 age-matched healthy volunteers were enrolled in the study. The MHD patients were divided into two groups according to the responsiveness to rHuEPO:22 cases with good responders and 18 cases with poor responders. The percentages of T cell subsets including CD+4 ,CD+8,CD+4/CD+28,CD+8/CD+28 T cell using flow cytometry were detected. Results The percentages of CD+4 and CD+8 T cell were lower in MHD patients than that in control group. The percentages of CD4+/CD+28 and CD+8/CD+28 T cell were lower in group of poor responders than in good responders.Conclusion Chronic inflammation state is common in MIlD patients. The percentages of CD+4/CD+28 and CD+8/CD+28 T cell in poor responders were much lower than good responders. The changes of T cell phenotypes may play a role in pathogenesis of hyporespousiveness to rHuEPO.
