Surveillance of Gram-negative bacterial resistance: data from Ministry of Health P. R. China National Antibacterial Resistance Investigation Net in 2004-2005
- VernacularTitle:2004-2005年卫生部全国革兰阴性菌细菌耐药性监测
- Author:
Yun LI
;
Yonghong XIAO
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Drug resistance,microbial;
Gram-negative bacteria;
Minimal inhibitory concentration;
Microbial sensitivity tests
- From:
Chinese Journal of Infectious Diseases
2008;26(4):202-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a national antibacterial resistance surveillance network and explore the epidemiology of bacterial resistance in China. Methods The minimal inhibitory concentration (MIC) was determined by National Committee for Clinical Laboratory Standards (NCCLS) standard agar double dilution method. The susceptibility and resistance rates of drugs were calculated according to the criteria in guidelines of NCCLS (2004). Results According to the previous protocol, a total of 4 075 pathogenic strains isolated from 17 hospitals located at 15 different cities from October 1, 2004 to September 30, 2005 in China were collected and the MICs were detected. Gram-negative bacilli were 3 150 strains ( 77.3%). Enterobacteriaceae Were highly susceptible to Carbapenems. In addition, Moxalactam, Piperacillin/Tazobactam, Cefoperazone/Sulbactam and Cefepime were also exhibited good antibacterial activities against Enterobacteriaceae,the resistance rates of them were less than 10 %. The resistance rates of nonfermentative Gramnegative bacilli, such as Pseudomonas aeruginosa and Acinetobacter baumanii, to Imipenem were 10. 6 % and 10.4 % , respectively. Cefoperazone/Sulbactam, Piperacillin/Tazobactam and Fluoroquinolones also showed good activity against nonfermentative Gram-negative bacilli.Conclusions The drug resistance rates of Escherichia coli and Acinetobacter baumanii increase obviously. Fluoroquinolones and Aminoglycosides are not very effective against Enterobacteriaceae,which should be paid more attention.
