Correlation between grey scale ultrasonographic feature and estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 expression in infiltrating ductal cancer of breast
- VernacularTitle:乳腺浸润性导管癌雌、孕激素受体及人类上皮生长因子受体表达与超声特征的关系
- Author:
Min CHEN
;
Junlai LI
;
Danfei SONG
;
Yan ZHANG
;
Yazhuo LI
;
Lixin WEI
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Breast neoplasms;
Receptors,estrogen;
Receptors,growth factor
- From:Chinese Journal of Ultrasonography
2008;17(4):333-335
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the grey scale ultrasonographic feature and estrogen receptor(ER),progesterone receptor(PR)or human epidermal growth factor receptor-2(HER-2)expression in infiltrating ductal cancer(IDC)of breast.Methods Seventy-three patients with IDC confirmed pathologically were involved in this study.The specimens wete examined immunohistochemistically to judge the expression of the related factors.ER,PR and HER-2 expression of the mastectomy specimens were determined with immunohistochemical staining technique.The correlation between the ultrasonographic features and ER,PR or HER-2 positive expression was analyzed. Results The ER positive rate in lesions with the spicule sign,echogenic halo or posterior shadowing were higher than in lesions without the spicule sign,echogenic halo or posterior shadowing(P＜0.01).The HER-2 positive rate in lesion with the calcifications and lymphadenectasis in axillary was higher than that in lesions without calcifications,or lymphadenectasis in axillary(P＜0.05).Conclusions A certain correlation exists between the ultrasonographic features and ER,HER-2 expression in patients with IDC.
