Comparison of the renal effects of Dopamine and Dobutamine in sepsis
- VernacularTitle:多巴胺及多巴酚丁胺对脓毒症患者肾功能的影响
- Author:
Haimei SUN
;
Wen ZHAO
- Publication Type:Journal Article
- Keywords:
Sepsis;
Vasoactive agent;
Renal function
- From:
Clinical Medicine of China
2008;24(4):297-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the renal effects of dopamine and dobutamine in patients with sepsis.Methods 90 patients with sepsis were admitted to this study.After resuscitation,each patient was randomly given different vasoactive agent.The changes in urine output,fractional excretion of sodium(FeNa),and creatinine clearance(CCr)were observed.Results The urine output and FeNa in dopamine group were increased significantly as compared with control group and dobutamine group[(3072±480),(2038±515)and(362±522)ml/24h,(3.80±1.09),(2.06±1.14)and(2.10±0.95)%](P<0.05).Compared with control group and dopamine group,CCr increased significantly in dobutamine group[(79.2±39.1),(50.6±21.8)and(47.4±16.7)ml/min](P<0.05).Conclusion Dopamine infusion markedly elevates urine output and FeNa,but has no effect on CCr.Dobutamine treatment misht significantly increase CCr,but has no effect on urine output.