Intermediate and long term clinical effects of uterine arterial embolization with sodium aiginate microspheres in treatment of diffuse adenomyosis
- VernacularTitle:海藻酸钠微球栓塞子宫动脉治疗弥漫型子宫腺肌病的中远期疗效观察
- Author:
Ping DUAN
;
Jing CHENG
;
Ming LIN
;
Lianlian CAI
;
Zhe HU
;
Shixiang JIN
;
Mingpin HU
- Publication Type:Journal Article
- Keywords:
Endometriosis;
Embolization,therapeutic;
Alginates;
Microspheres;
Treatmentoutcome
- From:
Chinese Journal of Obstetrics and Gynecology
2008;43(4):272-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study intermediate and long term efficacy of uterine arterial embolization (UAE)with sodium alginate microspheres(KMG)at diameters 500-700μm in treatment of diffuse adenomyosis.Methods Totally 40 patients with standard difluse adenomyosis were enrolled and treated with UAE.KMG at diameters 500-700 μm for vascular embolization were used to embolize the arteries.The degree of dysmenorrhea,amount of menorrhea and uterine volume,as well as the level of serum CA125,follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2)were investigated before andafter UAE.Results The follow up rates were 100%(40/40),100%(40/40),80%(32/40),68%(27/40),58%(23/40)after uterine arterial UAE 12,24,36,48 and 60 months respectively.The early,intermediate and long-term effective rates were 90%(36/40),88%(28/32),83%(19/23).The degree of dysmenorrhea,the amount of menorrhea and the uterine volume,as well as serum CA125 all decreased significantly 3 mouths after UAE at varying degrees(P＜0.05).Compared with other follow-up time,thedegree of dysmenorrhea and the amount of menorrhea declined to their lowest point at 6 month after UAE (P＜0.01).Paralleled with the decrease of volume of uterine,serum CA125 also decreased significantly and reached the lowest level 12 months later compared with other follow-up times(P＜0.01).Even at the 12th month after UAE serum CA125was not normal and FSH,LH and E2 did not change all the times after UAE(P>0.05).No recurrence was found during the 60 months after UAE.Condusion KMG used in UAE at diameters 500-700 μm has good intermediate and long term effectiveness in treatment of diffuse adenomyosis with no side effects.
