Application of neoadjuvant chemotherapy in cervical carcinoma
- VernacularTitle:宫颈癌术前介入化疗的效果分析
- Author:
Gaochuan LU
;
Jun XU
;
Lei SUN
;
Xiao LIN
;
Guoling ZHANG
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Chemotherapy,cancer,regional perfusion;
Cisplation;
Premedication
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(4):635-637
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic efficacy of neoadjuvant chemotherapy in cervical carcinoma. Methods TAC(DDP, EPI and BLM) was applied in 68 patients with cervical carcinoma. Therapeutic efficacy and side effects were documented. Results After 1～3 cycles of neoadjuvant chemotherapy, clinical symptoms remission rares reached 100% ,response rate were 100% (40/40) in Ⅰ b～Ⅱ a,90.9% (20/22) in Ⅱ b and 50% (2/4)in Ⅲ a, respectively. Radical resection reached 91.2 %, and only 6 patients of advanced disease failed to radical resection and turned to radiotherapy. Conclusion Neoadjuvant chemotherapy is a safe and effective therapeutic option which could alleviate clinical symptoms, decrease tumor size, down-staging and increase the radical resection rate.
