The dinical effect of rhG-CSF combined transplantation of autologous bone marrow mesenchymal stem cells on acute cerebral infarction
- VernacularTitle:G-CSF联合自体骨髓间充质干细胞移植治疗急性脑梗死的临床研究
- Author:
Hongbo SUN
;
Shengmei XIA
;
Shanshan YANG
;
Fengmin YANG
;
Jihong ZHANG
;
Jianghua LIU
;
Xuesong LI
;
Ting HE
;
Xiandong ZHANG
- Publication Type:Journal Article
- Keywords:
Granulocyte colony-stimulating factor/TU;
Mesenchymal stem cell transplation;
Brain infaretion/TH
- From:
Journal of Chinese Physician
2008;10(4):441-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of rhG-CSF combined transplantation of autologous bone marrow mesenchymal stem cells on cerebral infarction. Methods 42 acute cerebral infarction patients were randomly divided into tow groups: Injection rhGCSF combined autologous bone marrow mesenchymal stem cells group(treatment group, n=20)and conventionality therapy group(control group, n=22).The efficacy was assessed by National Institutes of Health Stroke Scale(NIHSS), Barthel Index(BI)and diffusion-weighted imaging(DWI),perfusion-weighted imaging(PWI)at baseline and the 3rd month after treatment. Result The scores of NHISS and BI treatment group were 4.8±2.0 and 78.5±7.2 respectively. while were 7.2±2.4 and 56.1±6.3 in control group at the 3rd month after treatment. The difference were significant(P＜0.01).PWI in treatment group Was higher than that in control group. There was no significant side-effect in treatment group. Conclusion rHG-CSF combined autologous bone marrow mesenchymal stem cells is a safe, efficient treatment for acute cerebral infarction patients, which is a better way than conventionality therapy.
