Observation of tirofiban's effect on myocardial necrosis biomarker in patients with aspitin resistance following percutaneous coronary interventions
- VernacularTitle:经皮冠状动脉介入治疗术后应用替罗非班对阿司匹林抵抗患者心肌坏死标志物的影响
- Author:
Yueping LI
;
Yujie ZHOU
;
Yan ZHANG
;
Yingxin ZHAO
;
Yuyang LIU
;
Hui YUAN
;
Lei DONG
- Publication Type:Journal Article
- Keywords:
Percutaneous coronary intervention;
Aspirin resistance;
GPⅡb/Ⅲa receptor antagonist;
Myocardial necrosis biomarker
- From:
Clinical Medicine of China
2008;24(5):443-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of tirofiban on myocardial necrosis biomarker after percutaneous coronary interventions(PCI)in patients with aspirin resistance(AR).Methods 374 consecutive patients with aspirin 100 mg≥1 week,receiving no other antiplatelet therapy,scheduled for PCI were enrolled.all patients were given an loading dose of 300 mg clopidogrel at least 12 hours before PCI and an 75 mg maintenance dose per day.Patients were randomized into tirofiban group(n=38)and control group(n=45)after PCI.The levels of CKMB,TnI at 8,12,and 24 hours after PCI were measured in all patients;if the CK-MB,TnI value was above normal upper limitation,it was considered elevated.Results 83 patients were AR(22.2%)and 54.2%of them are females.The frequencies of CK-MB elevation were 15(39.5%)in tirofiban group and 19(42.2%)in control group,and TnI elevation was 18(47.4%)and 23(51.1%)in the two groups respectively.Conclusion Tirofiban can not decrease the elevation level of CK-MB and TnI in patients with AR after PCI.
