Inhibition of Mongolian medicine naru-3 on the apoptosis of the mouse hepatic cells induced by radiation
- VernacularTitle:蒙药那如-3抑制辐射诱导小鼠肝细胞凋亡的影响研究
- Author:
Shaochun WU
;
Lin BU
- Publication Type:Journal Article
- Keywords:
Naru-3;
Hepatocy-tes;
Apoptosis;
Radiation injuries;
Mouse
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(4):616-618
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Mongolian medicine naru-3 on the apoptosis of mouse hepatic cells induced by radiation. Methods Kunming mice were radiated with 60Coγ-irradiation, the 30-day survival rate of mice and the average life span of dead mice post-irradiation were observed. The apoptosis of hepatic cells from irradiatied mice was detected by FACS and TUNEA expression level of p53 was examined. Results Administration of the medicine resulted in increase of 30-day survival rate and prolongation of average life span of the dead mice. The apoptosis rate of spleen cells from mice treated with Mongolian medicine naru-3 decreased significantly and the ex pression level of p53 was also inhibited significantly. Conclusion The results indicated that Mongolian medicine naru-3 had radio protective function and its mechanism might be related to the suppression of apoptosis of radiationsensitive cells.
