Expression level and significance of TGF-β1 and CTGF in cerebrospinal fluid of patients with subarachnoid hemorrhage
- VernacularTitle:TGF-β1和CTGF在蛛网膜下腔出血患者脑脊液中的表达水平变化及意义
- Author:
Bin YUAN
;
Tong LI
- Publication Type:Journal Article
- Keywords:
Transforming growth factor beta;
Connective tissue;
Subarachnoid hemorrhage;
Cerebrospinal fluid
- From:
Journal of Chinese Physician
2008;10(4):439-440
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of TGF-β1 and CTGF in the occurrence and development of patients with subarachnoid hemorrhage. Methods Cerebrospinal fluid TGF-β1 and CTGF concentrations in all subjects were serially detected by ELISA. Results Mean total TGF-β1 and CTGF in patients were elevated more than that in controls at the first day(P＜0.05).Thereafter the levels of TGF-β1 and CTGF fell by the third day, then rose to the second peak at the tenth day and remained significantly increase until the sixteenth day(P＜0.05).The levels of TGF-β1 was positive correlated CTGF. Conclusion The expressions of TGF-β1 and CTGF in patients with subarachnoid hemorrhage showed two peaks character. After SAH, the concentration of TGF-β1 and CTGF concentration is related to chronic communicating hydrocephalus.
