The correlation between MCP-1 and cardiovascular complication of diabetes
- VernacularTitle:单核细胞趋化蛋白-1与糖尿病心血管并发症的相关分析
- Author:
Kai LIU
;
Aihua CHEN
;
Dehong CAI
;
Yun WU
;
Wanying LUO
- Publication Type:Journal Article
- Keywords:
Monocyte chemoattractant protein-1;
Diabetic angiopathy
- From:
Journal of Chinese Physician
2008;10(4):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance and correlation between MCP-1 and cardiovascular complication of diabetes. Methods 65 patients with diabetes and 64 patents with IGT and 60 healthy persons as control group are chosen from a population of 1231residents at Jiangnan community in Guangzhou city. Ultrasonic inspection of carotid artery was applied to the intimae media thickness (IMT),and the levels of-MCP-1 were detected by Elisa. Result There was significant difference in the levels of MCP-1 among the normal control group, IGT group and DM group (P=0.000).The levels of MCP-1 in IGT complicated with AS patients were significantly higher than that in IGT alone patients. The levels of MCP-1 in DM complicated with AS patients were significantly higher than that in DM alone patients. The levels of MCP-1 were positively correlated with IMT in these patients. A forward LR Logistic regression analysis showed that IMT was a dependent variable, gender, MCP-1 and age are independently correlated with IMT. Conclusion MCP-1 is correlated with diabetes and its cardiovascular complication and it may be served as the target of therapy.
