A study on the expression of erbB4/HER4 and VEGF in NSCLC
- VernacularTitle:erbB4/HER4与VEGF在非小细胞肺癌中的表达研究
- Author:
Zaichun DENG
;
Yiming YU
;
Gun CHEN
;
Guoping ZHONG
;
Yunshan TAN
;
Yonghua XU
;
Chunxue BAI
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-smal-cell lung;
Vascular endothelial growth factors;
Genes,erbB
- From:
Journal of Chinese Physician
2008;10(4):475-477
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To explore the expression of HER4 and VEGF in NSCLC and elucidate the relationship between their expression and the characteristic of clinical pathology. Methods 82 cases of paraffin-embedded tissues from informative NSCLC were used to detect the expression of HER4 and VEGF by means of immunohistochemical assay. Results HER4 is overexpressed in 65;9%of NSCLC cases. The overexpression of HER4 is correlated with the lymph node metastasis and TNM staging. VEGF is expressed in 53.7%of NSCLC cases. The expression of VEGF is also correlated with the lymph node metastasis and TNM staging, and the expression of VEGF is correlated with the overexpression of HER4.Conclusions HER4 and VEGF are the protein to regulate the growth of NSCLC and it might be a good way for the treatment of NSCLC by suppressing the overexpression of HER4 and VEGF.
