Influence of atorvustatin on clinical therapeutic effect of cerebral infarction and lipid lowering,C-reactive protein level
- VernacularTitle:阿托伐他汀治疗急性脑梗死及对调脂、C反应蛋白水平的影响
- Author:
Kaixiang LIU
;
Junlin FENG
;
Jingzi JIANG
;
Aiyuan ZENG
;
Lan WU
;
Jianfeng LIN
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Hyperlipidemias;
C-reactive protein;
Atorvastatin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(4):598-599
- CountryChina
- Language:Chinese
-
Abstract:
Objective It is to observe the influence of atorvastat on the clinical therapeutic effect in the patients with cerebral infarction and lipid lowering, C-reactive protein level. Methods 60 patients with cerebral infarction are admined by atorvastatin 20mg,orally taking, 1 time per day,course of treatment for 4 weeks. Observing the variation of the high sensitivity C-reactive protein(hs-CRP) and concentration of blood fat in the circa about treatment. Results Treatment group's excellence rate is 70.0 %, total effective rate is 86.7 % after 4 weeks' atorvastatin treatment. It obviously outweighs the control group(43.3 % and 66.7 % ) ( P＜0.05 ) without evident adverse effect; TC, LDL-C significantly step clown and HDL-C(P＜0.05 ) significantly steps up comparing pretherapy. They also obviously outweigh the control group(P＜0.05 and P＜0.01 ). The blood serum hs-CRP level obviously decreases( P＜0.01 ). Conclusion Atorvastat can not only lower the lipid, but also degrade the concentration of CRP.It has significant clinical therapeutic effect while without evident adverse effect. The early use of atorvastatin can prevent and control ischemic cerebrovascular disease preferably. It can also reduce the genesis of cerebrovascular disease and improve the prognosis of cerebrovascular disease.
