The minimal local analgesic dose of hypobaric levobupivacaine in elderly patients undergoing spinal anesthesia during unilateral lower limb surgery
- VernacularTitle:轻比重左旋布比卡因用于老年患者单侧腰椎麻醉的最低有效剂量
- Author:
Wenhua WAN
;
Yunhua WANG
;
Xin CHEN
;
Chunhua LIU
;
Zhihao TANG
;
Shuaishuai REN
- Publication Type:Journal Article
- Keywords:
Dose-response relationship,drug;
Anesthetics;
Surgical procedure,oporative;
Lower extremity
- From:
Chinese Journal of Geriatrics
2008;27(5):346-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the minimal local analgesic dose (MLAD) of hypobaric levobupivacaine in elderly patients undergoing spinal anesthesia during lower limb surgery. Methods A total of 25 patients underwent spinal anesthesia with hypobaric levobupivacaine during lower limb surgery. The initial dose of levobupivaeaine was 7.50 mg for the first patient. The dose for next patient was added by 0.25 mg if the level of sensory block was lower than that of T10, conversely the dose was subtracted by 0.25 mg. The MLAD of hypobaric levobupivacaine was calculated with up-and-down sequential experiment according to Dixon-Messay method. Results The MLAD of hypobaric levobupivacaine were 6.67 mg (95% confidence interval: 6.34-7.25). The anesthesia effects of all patients were good. The degree of motor blockade of the healthy leg was less than another leg.The intraoperative and postoperative complications rates associated with spinal anesthesia were low.Conclusions The MLAD of hypobaric levobupivacaine is 6.67 mg in elderly patients undergoing spinal anesthesia during unilateral lower limb surgery.
